TPN dependent, but stopped or unavailable?
Cephalosporin allergy?
Grown high risk isolate in past 3 months?
Meet SIRS criteria?
Severe sepsis?
Adequate response?
Fever in this population is an emergency
Population specific information
Goal: Administer empiric antibiotics via central venous catheter within 1 hour of presentation.
Viral URI AND Tmax < 38.5 C?
Inspect all CVCs for integrity as line breaks/cracks are risk factors for infection, then obtain labs.
SIRS criteria (≥ 2 criteria, one of which must be abnormal temperature or WBC)
High-risk blood-stream isolates
Inpatient management includes: